Hagan Bayley is the Professor of Chemical Biology at the University of Oxford. A major interest of his laboratory is the development of engineered protein nanopores for stochastic detection, including single-molecule covalent chemistry and ultrarapid biopolymer sequencing. Recently, the Bayley lab has developed techniques for the fabrication of 3D tissues, both living and synthetic. In 2005, Professor Bayley founded Oxford Nanopore, which has manufactured the portable MinION and other DNA/RNA sequencers. Professor Bayley was the 2009 Chemistry World Entrepreneur of the Year. In 2011, he was elected a Fellow of the Royal Society. In 2012 he was awarded the Royal Society of Chemistry’s Interdisciplinary Prize, in 2017 the Menelaus Medal of the Learned Society of Wales and in 2019 the Mullard Award of the Royal Society. In 2018, Professor Bayley held the Kavli Chair at the Delft University of Technology and he is currently a Lead Researcher of the Oxford Martin School.
About his talk: The Remarkable Science of Nanopores: from Gene Sequencing to Organ Repair
We have produced engineering protein nanopores that have several uses in biotechnology. One major application is the stochastic detection of small molecules and the ultrarapid sequencing of biopolymers, such as DNA and RNA. Protein nanopores can also be used to investigate many aspects of single-molecule covalent chemistry, including walking and hopping molecules. In a second major application, we have used engineered pores to facilitate communication in 3D printed synthetic tissues. mm-Scale printed structures can be used as building blocks for larger structures containing both synthetic and living cells that have potential applications in regenerative medicine.